Life isn't easy when you have Puppetitis B. Just ask Callie Williams, who comes down with the dread disease and suddenly has an evil puppet growing out of her hand. Izzy (the puppet) is a cute, furry sociopath with a lusty sex drive, a mind for business, and a passion for ruining people's lives. Yet, deep down, is Izzy truly friend or foe? Pal or parasite? And who, exactly, is doing the puppeteering in this relationship?